With POTUS and members of Congress in the Big Easy for a political convention, an unidentified killer virus in the Crescent City emergency room has physicians baffled, hospital staff frightened, and the CDC on their way to assist. When the first death from the mysterious virus is a Secret Service agent guarding the President, a terrorist attack is feared. Matters get worse with the murder of a prominent politician in the French Quarter. Alex and Jack must learn to play well with the CDC, FBI, and Secret Service and enlist the help of the enemy to save the streets of New Orleans from disaster.