'On the Origin of Species' is the great work of Darwin's life. The whole first edition of 1250 copies was exhausted on the day of issue. The first four chapters explain the operation of artificial selection by man and of natural selection in consequence of the struggle for existence. The fifth chapter deals with the laws of variation and causes of modification other than natural selection. The five succeeding chapters consider difficulties in the way of a belief in evolution generally as well as in natural selection. The three remaining chapters (omitting the recapitulation which occupies the last) deal with the evidence for evolution. The theory which suggested a cause of evolution is thus given the foremost place, and the evidence for the existence of evolution considered last of all.