Oxygen opens with anaesthesiologist Marie Heaton facing a nightmarish operating room disaster which ends a child's life and launches a tangled malpractice suit. As Marie twists through depositions, accusations and a remorseful preoccupation with the mother of the dead child, a quieter crisis is unfolding within her own family.
Her aging father is losing his sight and approaching an awkward dependency on Marie and her sister, Lori. But Lori has taken a more traditional path than Marie, and is busy raising a family.
Although she has been estranged from him for decades, the ultimate responsibility for their father's care is falling on Marie. As her carefully structured life begins to shatter, Marie confronts questions of love and betrayal, family bonds, and the price of her own choices...