Androcles, a fugitive Christian tailor, accompanied by his nagging wife, is on the run from his Roman persecutors. While hiding in the forest he comes upon a wild lion who approaches him with a wounded paw. His wife runs off. Androcles sees that the cause of the animal's distress is a large thorn embedded in its paw, which he draws out while soothing the lion in baby language.
The play was written at a time when the Christian Church was an important influence on society and there was strong pressure on non-believers in public life. The reversal of roles in the play possibly served to evoke empathy from his targeted audience. The characters also represent different "types" of Christian believers.